Minipig Translational Research Models
نویسنده
چکیده
Miniature swine have been utilized as translational research models with outcomes in high concordance with humans in a variety of systems. Much of the data justifying the minipig models has been published in books and review manuscripts.1-16 Summary publications of some of the major models have also been published online (http://www.sinclairresearch.com/Literature/Literature. aspx). Major systems utilized in these types of studies are: cardiovascular, dermal, digestive, urogenital, neurologic, ophthalmic, and musculoskeletal. This manuscript will discuss areas where swine have been demonstrated to be translational models with direct application to humans.
منابع مشابه
The Göttingen minipig in translational neuroscience
introduction Animal models are essential in the development of novel treatment paradigms for most diseases, and for decades rodent models of various diseases have been imperative. The translation of results and treatment options from these small animals to humans often requires the use of a large animal as an intermediate step. Nonhuman primates have been used for this purpose, as this species ...
متن کاملModeling the growth of the Goettingen minipig.
The Goettingen minipig developed at the University of Goettingen, Germany, is a special breed for medical research. As a laboratory animal it has to be as small and light as possible to facilitate handling during experiments. For achieving the breeding goal of small body size in the future, the growth pattern of the minipig was studied. This study deals with the analysis of minipig BW by modeli...
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Pyogenic hepatic abscess (PHA) is a rare but potentially serious disease. Investigations of new therapeutic methods urgently need experimental support in corresponding animal models. However, to date, few studies have evaluated PHA in the minipig. The linear regression equation of the Staphylococcus aureus ATCC 25923 strain was established. PHA was successfully mocked, and S. aureus ATCC 29213 ...
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